Objectives
The knowledge of biological effects of proton irradiation is of crucial importance in Proton
Therapy (PT) for clinical dose prescription (Tumor Control Probability TCP) and for Normal Tissue
Complication Probability (NTCP). However, they depend on many variables like p + incident energy, tissue
cells type, penetration depth, dose rate (FLASH-PT), and endpoint, and are thus not well understood. Various
aspects of radiation effects will be considered, from projectile-biological molecule collisions to ion track
simulations and radiobiological experiments.

The objectives of this WP are:
1) to conduct theoretical and experimental studies of the impact of different radiation qualities on cells, with
focus on both nuclear and membrane damage.

2) to conduct theoretical and experimental studies of the impact of different radiation qualities on cells, with
focus on both nuclear and membrane damage.

3) to improve the cross sections introduced in Monte Carlo codes for particle tracks to obtain a more reliable
calculation of energy deposition at the scale of biomolecules

4) to investigate different hypothesis for FLASH effect for photon and proton beams

5) to improve the evaluation of TCP and NTCP for clinical PT and space radiation radioprotection

Lead beneficiary: TIFPA